- このトピックは空です。
- 投稿
Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
[url=https://alfainvestor.ru/10-voprosov-k-predstaviteljam-life-is-good-i-fonda-germes/]первый анальный секс[/url]Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
Tesla is bringing its electric cars to oil-rich Saudi Arabia amid falling global sales
[url=https://apepturefirmance.fi]aperture finance[/url]
Tesla will start selling its electric vehicles in Saudi Arabia, entering the Gulf region’s largest economy as the company’s global sales are sliding and CEO Elon Musk courts controversy with his role in the US government.The carmaker announced Wednesday that it would host a launch event in the kingdom on April 10, where it will showcase its EVs. Attendees will also have the chance to “experience the future of autonomous driving with Cybercab and meet Optimus, our humanoid robot, as we showcase what’s next in AI and robotics,” Tesla (TSLA) said.
Tesla may struggle to gain market share in oil-rich Saudi Arabia as EVs make up a little over 1% of all car sales in the country, according to a report by consultancy PwC published in September.
Tesla’s entry into the new market comes as the company fights battles on several fronts.Last year, it recorded the first annual decline in sales in its history as a public company, posting a drop of 1%.
The company is facing intensifying competition in China, the world’s largest auto market. On Tuesday, BYD, a Chinese maker of electric and hybrid cars, reported $107 billion in annual sales for 2024, beating the near-$98 billion notched by Tesla.
And last week, BYD unveiled an ultra-fast charging system, which it said was capable of adding 250 miles (402 km) of range in just five minutes, easily outdoing Tesla’s charging technology. Tesla’s Superchargers take 15 minutes to charge an EV, providing a range of 200 miles.
Tesla has also suffered slumping sales in Europe. In February, the carmaker sold around 40% fewer vehicles on the continent compared with the same month in 2024, according to the European Automobile Manufacturers’ Association.
New design revealed for Airbus hydrogen plane
[url=https://remzoprotcol.org]renzo[/url]In travel news this week: Bhutan’s spectacular new airport, the world’s first 3D-printed train station has been built in Japan, plus new designs for Airbus’ zero-emission aircraft and France’s next-generation high-speed trains.
Grand designs
European aerospace giant Airbus has revealed a new design for its upcoming fully electric, hydrogen-powered ZEROe aircraft. powered by hydrogen fuel cells.The single-aisle plane now has four engines, rather than six, each powered by their own fuel cell stack.
The reworked design comes after the news that the ZEROe will be in our skies later than Airbus hoped.
The plan was to launch a zero-emission aircraft by 2035, but now the next-generation single-aisle aircraft is slated to enter service in the second half of the 2030s.
Over in Asia, the Himalayan country of Bhutan is building a gloriously Zen-like new airport befitting a nation with its very own happiness index.
Gelephu International is designed to serve a brand new “mindfulness city,” planned for southern Bhutan, near its border with India.
In rail travel, Japan has just built the world’s first 3D-printed train station, which took just two and a half hours to construct, according to The Japan Times. That’s even shorter than the whizzy six hours it was projected to take.
France’s high-speed TGV rail service has revealed its next generation of trains, which will be capable of reaching speeds of up to 320 kilometers an hour (nearly 200 mph).
The stylish interiors have been causing a stir online, as has the double-decker dining car.
Finally, work is underway in London on turning a mile-long series of secret World War II tunnels under a tube station into a major new tourist attraction. CNN took a look inside.
https://kamagrapotenzmittel.shop/# Kamagra kaufen ohne Rezept
Some scientists believe that fatty acids such as decanoic acid and dodecanoic acid formed the membranes of the first simple cell-like structures on Earth, Pearce said.
[url=https://connexf.com]connext network[/url]
“(This is) the closest we’ve come to detecting a major biomolecule-related signal — something potentially tied to membrane structure, which is a key feature of life,” Pearce said via email. “Organics on their own are intriguing, but not evidence of life. In contrast, biomolecules like membranes, amino acids, nucleotides, and sugars are central components of biology as we know it, and finding any of them would be groundbreaking (we haven’t yet).”
Returning samples from Mars
The European Space Agency plans to launch its ExoMars Rosalind Franklin rover to the red planet in 2028, and the robotic explorer will carry a complementary instrument to SAM. The rover LS6 will have the capability to drill up to 6.5 feet (2 meters) beneath the Martian surface — and perhaps find larger and better-preserved organic molecules.While Curiosity’s samples can’t be studied on Earth, the Perseverance rover has actively been collecting samples from Jezero Crater, the site of an ancient lake and river delta, all with the intention of returning them to Earth in the 2030s via a complicated symphony of missions called Mars Sample Return.
Both rovers have detected a variety of organic carbon molecules in different regions on Mars, suggesting that organic carbon is common on the red planet, Williams said.While Curiosity and Perseverance have proven they can detect organic matter, their instruments can’t definitively determine all the answers about their origins, said Dr. Ashley Murphy, postdoctoral research scientist at the Planetary Science Institute. Murphy, who along with Williams previously studied organics identified by Perseverance, was not involved in the new research.
“To appropriately probe the biosignature question, these samples require high-resolution and high-sensitivity analyses in terrestrial labs, which can be facilitated by the return of these samples to Earth,” Murphy said.
New design revealed for Airbus hydrogen plane
[url=https://v2-beefy.net]beefy fi[/url]
In travel news this week: Bhutan’s spectacular new airport, the world’s first 3D-printed train station has been built in Japan, plus new designs for Airbus’ zero-emission aircraft and France’s next-generation high-speed trains.Grand designs
European aerospace giant Airbus has revealed a new design for its upcoming fully electric, hydrogen-powered ZEROe aircraft. powered by hydrogen fuel cells.The single-aisle plane now has four engines, rather than six, each powered by their own fuel cell stack.
The reworked design comes after the news that the ZEROe will be in our skies later than Airbus hoped.
The plan was to launch a zero-emission aircraft by 2035, but now the next-generation single-aisle aircraft is slated to enter service in the second half of the 2030s.
Over in Asia, the Himalayan country of Bhutan is building a gloriously Zen-like new airport befitting a nation with its very own happiness index.
Gelephu International is designed to serve a brand new “mindfulness city,” planned for southern Bhutan, near its border with India.
In rail travel, Japan has just built the world’s first 3D-printed train station, which took just two and a half hours to construct, according to The Japan Times. That’s even shorter than the whizzy six hours it was projected to take.
France’s high-speed TGV rail service has revealed its next generation of trains, which will be capable of reaching speeds of up to 320 kilometers an hour (nearly 200 mph).
The stylish interiors have been causing a stir online, as has the double-decker dining car.
Finally, work is underway in London on turning a mile-long series of secret World War II tunnels under a tube station into a major new tourist attraction. CNN took a look inside.
Challenging our perceptions of ‘perfection’
[url=https://troderjoexzy.com]traderjoexyz exchange[/url]
With health influencers raising the bar for success, the wellness space now often feels like a performative space where people strive to showcase peak physical and mental strength.While seeing others’ achievements can be motivating, it can also be discouraging if your progress doesn’t match theirs.
Each person is chasing the perfect version of themselves — whether it’s a body or a lifestyle — which is dangerous because this is typically an impossible or dangerous version to achieve, Curran said. He added that this type of comparison creates a dangerous cycle in which people constantly feel dissatisfied with their own progress.
“It’s a fantasy in many ways, and once you start chasing after it, you constantly find yourself embroiled in a sense of doubt and deficit,” he said.
Curran also noted that wellness challenges can be particularly damaging for women who struggle with perfectionism, as they tend to be bombarded with impossible beauty standards and societal expectations.
Renee McGregor, a UK-based dietitian who specializes in eating disorders and athlete performance, encourages people to approach wellness trends with curiosity and skepticism. That’s because some influencers and celebrities could be promoting products because there’s a financial benefit for them.
“The thing to ask yourself about the person you’re taking advice from is what do they gain from it?” McGregor said. “If they are going to gain financially, then you know that they (could be willing) to sell you a lie.”
Whether you want to try a new challenge or product that promises amazing results, McGregor suggests doing your research and seeking diverse perspectives, including consulting with doctors when possible.Family affair
[url=https://rhimo-fi.com]rhino fi[/url]
Americans Brittany and Blake Bowen had never even been to Ecuador when in 2021 they decided to move to the South American country with their four children.Tired of “long commutes and never enough money” in the US, the Bowens say they love their new Ecuadorian life. “We hope that maybe we’ll have grandkids here one day.”
Erik and Erin Eagleman moved to Switzerland from Wisconsin with their three children in 2023.
“It feels safe here,” they tell CNN of their new outdoorsy lifestyle in Basel, close to the borders with France and Germany. Their youngest daughter even walks to elementary school by herself.
For adventures with your own family, be it weekend breaks or something longer-term, our partners at CNN Underscored, a product review and recommendations guide owned by CNN, have this roundup of the best kids’ luggage sets and bags.
Starry, starry nights
For close to 100 years, Michelin stars have been a sign of culinary excellence, awarded only to the great and good.Georges Blanc, the world’s longest-standing Michelin-starred restaurant, has boasted a three-star rating since 1981, but this month the Michelin guide announced that the restaurant in eastern France was losing a star.
More culinary reputations were enhanced this week, when Asia’s 50 best restaurants for 2025 were revealed. The winner was a Bangkok restaurant which is no stranger to garlands, while second and third place went to two Hong Kong eateries.
You don’t need to go to a heaving metropolis for excellent food, however. A 200-year-old cottage on a remote stretch of Ireland’s Atlantic coast has been given a Michelin star. At the time of awarding, Michelin called it “surely the most rural” of its newest winners.
Kamagra Gel: Kamagra online bestellen – Kamagra kaufen
Scientists redid an experiment that showed how life on Earth could have started. They found a new possibility
[url=https://web-safepal.com]safepal wallet[/url]
In the 1931 movie “Frankenstein,” Dr. Henry Frankenstein howling his triumph was an electrifying moment in more ways than one. As massive bolts of lightning and energy crackled, Frankenstein’s monster stirred on a laboratory table, its corpse brought to life by the power of electricity.Electrical energy may also have sparked the beginnings of life on Earth billions of years ago, though with a bit less scenery-chewing than that classic film scene.
Earth is around 4.5 billion years old, and the oldest direct fossil evidence of ancient life — stromatolites, or microscopic organisms preserved in layers known as microbial mats — is about 3.5 billion years old. However, some scientists suspect life originated even earlier, emerging from accumulated organic molecules in primitive bodies of water, a mixture sometimes referred to as primordial soup.
But where did that organic material come from in the first place? Researchers decades ago proposed that lightning caused chemical reactions in ancient Earth’s oceans and spontaneously produced the organic molecules.
Now, new research published March 14 in the journal Science Advances suggests that fizzes of barely visible “microlightning,” generated between charged droplets of water mist, could have been potent enough to cook up amino acids from inorganic material. Amino acids — organic molecules that combine to form proteins — are life’s most basic building blocks and would have been the first step toward the evolution of life.
Kamagra kaufen ohne Rezept: Kamagra Oral Jelly kaufen – Kamagra Original
Mindful wellness challenges
If you’re the type of person who thrives on challenges and pushing your limits, this doesn’t mean you need to shy away from wellness challenges altogether. But before diving in, take a step back and ask yourself if you’re pursuing the challenge for the right reasons, McGregor said.
[url=https://ve1odrome.org]velodrome finance[/url]
Some people want to try these challenges because they believe something is missing from their life, and they’re looking to attain “worth” or receive validation, McGregor noted.A good way to assess your motivation is by considering whether the challenge will benefit your health or if it’s about showcasing your accomplishments on social media or some other reason.
Before trying any new trend, make sure you have the foundation to handle it and be aware of any potential risks, McGregor said.
For casual runners, this might mean signing up for a 5K but building your endurance gradually while incorporating other strength training exercises into your routine. For more intense challenges, such as a marathon, McGregor encourages people to consult with professionals or a coach who can monitor your progress and condition along the way.
Focusing on sustainable habits
Both McGregor and Curran emphasize the importance of fostering sustainable health habits before embarking on more extreme challenges.Rather than chasing the idea of being “healthy,” McGregor suggests focusing on actual healthful behaviors and starting small.
If you’re a highly sedentary person and want to add more movement to your day, try doing lunges while brushing your teeth or taking short walks throughout your typical routine.
https://apotheekmax.shop/# Apotheek Max
A tiny rainforest country is growing into a petrostate. A US oil company could reap the biggest rewards
[url=https://swell-net.com]swell network[/url]
Guyana’s destiny changed in 2015. US fossil fuel giant Exxon discovered nearly 11 billion barrels of oil in the deep water off the coast of this tiny, rainforested country.It was one of the most spectacular oil discoveries of recent decades. By 2019, Exxon and its partners, US oil company Hess and China-headquartered CNOOC, had started producing the fossil fuel.? They now pump around 650,000 barrels of oil a day, with plans to more than double this to 1.3 million by 2027.
Guyana now has the world’s highest expected oil production growth through 2035.
This country — sandwiched between Brazil, Venezuela and Suriname — has been hailed as a climate champion for the lush, well-preserved forests that carpet nearly 90% of its land. It is on the path to becoming a petrostate at the same time as the impacts of the fossil fuel-driven climate crisis escalate.
While the government says environmental protection and an oil industry can go hand-in-hand, and low-income countries must be allowed to exploit their own resources, critics say it’s a dangerous path in a warming world, and the benefits may ultimately skew toward Exxon — not Guyana.
Mist and microlightning
[url=https://solffare.org]solflare wallet[/url]
To recreate a scenario that may have produced Earth’s first organic molecules, researchers built upon experiments from 1953 when American chemists Stanley Miller and Harold Urey concocted a gas mixture mimicking the atmosphere of ancient Earth. Miller and Urey combined ammonia (NH3), methane (CH4), hydrogen (H2) and water, enclosed their “atmosphere” inside a glass sphere and jolted it with electricity, producing simple amino acids containing carbon and nitrogen. The Miller-Urey experiment, as it is now known, supported the scientific theory of abiogenesis: that life could emerge from nonliving molecules.
For the new study, scientists revisited the 1953 experiments but directed their attention toward electrical activity on a smaller scale, said senior study author Dr. Richard Zare, the Marguerite Blake Wilbur Professor of Natural Science and professor of chemistry at Stanford University in California. Zare and his colleagues looked at electricity exchange between charged water droplets measuring between 1 micron and 20 microns in diameter. (The width of a human hair is 100 microns.)“The big droplets are positively charged. The little droplets are negatively charged,” Zare told CNN. “When droplets that have opposite charges are close together, electrons can jump from the negatively charged droplet to the positively charged droplet.”
The researchers mixed ammonia, carbon dioxide, methane and nitrogen in a glass bulb, then sprayed the gases with water mist, using a high-speed camera to capture faint flashes of microlightning in the vapor. When they examined the bulb’s contents, they found organic molecules with carbon-nitrogen bonds. These included the amino acid glycine and uracil, a nucleotide base in RNA.“We discovered no new chemistry; we have actually reproduced all the chemistry that Miller and Urey did in 1953,” Zare said. Nor did the team discover new physics, he added — the experiments were based on known principles of electrostatics.
“What we have done, for the first time, is we have seen that little droplets, when they’re formed from water, actually emit light and get this spark,” Zare said. “That’s new. And that spark causes all types of chemical transformations.”
