HDAC inhibitors exert their anti tumor effects via the induction of expression changes of oncogenes or tumor suppressor, through modulating the acetylation deacetylation of histones and or non histone proteins such as transcription factors generic cialis 5mg Accordingly, we expected to enroll approximately 44 patients with wt wt to enroll 136 patients with wt V or V V based on the current frequencies of CYP2D6 genotypes in this study wt wt wt V or V V 25 75